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Synthesis of a [11C]Methoxy derivative of α-Dihydrotetrabenazine: a radioligand for studying the vesicular monoamine transporter

✍ Scribed by Jean N. DaSilva; Michael R. Kilbourn; Thomas J. Mangner


Book ID
103989218
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
248 KB
Volume
44
Category
Article
ISSN
0969-8043

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Synthesis of [11C]tetrabenazine, a vesic
✍ Jean N. DaSilva; Michael R. Kilbourn; Thomas J. Mangner 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 393 KB

Tetrabenazine (TBZ), a high affinity and specific inhibitor of the vesicular monoamine transporter, has been labeled with carbon-11 as a potential probe for in vivo positron emission tomographic imaging of monoaminergic neuronal losses in neurodegenerative diseases. [11C]TBZ was synthesized by O-[11