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Synthesis and Biological Evaluation of 10- 11 C-Dihydrotetrabenazine as a Vesicular Monoamine Transporter 2 Radioligand

✍ Scribed by Li, Xiaomin; Chen, Zhengping; Tang, Jie; Liu, Chunyi; Zou, Pei; Huang, Hongbo; Tan, Cheng; Yu, Huixin


Book ID
121797413
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
294 KB
Volume
347
Category
Article
ISSN
0365-6233

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✍ Daniel J. Canney; Yu-Zhi Guo; Mei-Ping Kung; Hank F. Kung πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 French βš– 718 KB

## Abstract A derivative of tetrabenazine (TBZ, __1__) containing an iodovinyl group (I‐TBZ, __3b__) was prepared as a potential radiotracer for the vesicular monoamine transporter. The synthesis of __3a__ was achieved by ethynylation of TBZ. The ethynyl derivative __4__, was converted to the corre