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Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands

✍ Scribed by Guangrong Zheng; Linda P. Dwoskin; Agripina G. Deaciuc; Peter A. Crooks


Book ID
108073741
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
139 KB
Volume
15
Category
Article
ISSN
0960-894X

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## Abstract A derivative of tetrabenazine (TBZ, __1__) containing an iodovinyl group (I‐TBZ, __3b__) was prepared as a potential radiotracer for the vesicular monoamine transporter. The synthesis of __3a__ was achieved by ethynylation of TBZ. The ethynyl derivative __4__, was converted to the corre