Radioimmunoassay for the new antiarrhythmic agent cibenzoline in human plasma

✍ Scribed by Ross Dixon; John Carbone; Jeff Tilley; Yu-Ying Liu

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 278 KB
• Volume: 72
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600720129

✦ Synopsis

as well as differences in the two standard deviations, and since the means themselves are tested for equality in the ANOVA, the 75/75 Rule also might be said to place the test product in double jeopardy.

The stress placed previously (1) on a "well-defined ref-

erence standard which has reproducible pharmacokinetic properties in terms of absorption and clearance" or "an oral solution" makes us ask just where the criterion of acceptable reproducibility of a reference standard is set down?

(1) B. E. Cabana, J. Pharrn. Sci., 72,98 (1983).

(2) J. D. Haynes, ibid, 70,673 (1981). 2, Hafner, New York, N.Y., 1973, p. 531. ' (3) M. G. Kendall, "The Advanced Theory of Statistics," 3rd ed., vol.