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Radioimmunoassays for a new angiotensin-converting enzyme inhibitor, zabicipril, and its active metabolite, zabiciprilat, in human plasma

✍ Scribed by E. Lelievre; H. Cardona; M. H. Brillanceau; C. Piraube; C. Sauveur


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
634 KB
Volume
81
Category
Article
ISSN
0022-3549

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The disposition characteristics of pentopril (the ethyl ester) and its active carboxylic acid metabolite (CGS 13934) were determined in conscious rats after separate intravenous administrations of both compounds. The relationship between plasma concentration and pharmacological effect was also evalu