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Radiochemical and biological characteristics of 99mTc-difloxacin and 99mTc-pefloxacin for detecting sites of infection

✍ Scribed by M. A. Motaleb

Publisher
John Wiley and Sons
Year
2010
Tongue
French
Weight
212 KB
Volume
53
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The optimization of the radiolabeling yield of ciprofloxacin analogous, difloxacin and pefloxacin, with ^99m^Tc was described. At pH 4, difloxacin was labeled with ^99m^Tc with a labeling yield of 95.6% by adding ^99m^Tc to 5 mg difloxacin in the presence of 100 µg SnCl~2~·2H~2~O whereas ^99m^Tc‐pefloxacin was labeled (98.1%) by adding ^99m^Tc to 4 mg pefloxacin in the presence of 50 µg SnCl~2~·2H~2~O. The radiochemical purity for both labeled compounds was evaluated with ITLC and HPLC system. Biological distribution of ^99m^Tc‐difloxacin and ^99m^Tc‐pefloxacin was carried out in experimentally induced infection rats, in the left thigh, using Staphylococcus aureus. Both thighs of the rats were dissected and counted and the ratio of bacterial infected thigh/contralateral thigh was then evaluated. T/NT for both ^99m^Tc‐difloxacin and ^99m^Tc‐pefloxacin was found to be 5.5±0.5 and 4.9±0.3, respectively, which was higher than that of the commercially available ^99m^Tc‐ciprofloxacin. Copyright © 2010 John Wiley & Sons, Ltd.

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