Synthesis and biological characterization of 99mTc(I) tricarbonyl cysteine complex, a potential diagnostic for assessment of renal function

✍ Scribed by Sang Hyun Park; Beom Su Jang; Kyung Bae Park

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: French
• Weight: 145 KB
• Volume: 48
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.897

✦ Synopsis

Abstract

Cysteine containing three functional groups, i.e. a carboxyl, sulfhydryl, and amino group, has been labelled with ^99m^Tc(I) tricarbonyl precursor (2) in order to study the renal characteristics of the resulting ^99m^Tc(I) tricarbonyl cysteine (3) versus the reference ^99m^Tc‐MAG~3~ (1). The ^99m^Tc(I) tricarbonyl cysteine (3) was prepared in good yields and characterized by HPLC, eletrophoresis, and eletrospray mass spectrometry. The plasma protein binding rate of ^99m^Tc(I) tricarbonyl cysteine (3) was about 70 to 80%, and similar to that of ^131^I‐OIH (70%) but lower than that of ^99m^Tc‐MAG~3~ (90%). The T~1/2~ of ^99m^Tc(I) tricarbonyl cysteine (4.30±0.79 min) in the kidney was higher than the one of ^99m^Tc‐MAG~3~ (2.43±0.70 min). The static image of ^99m^Tc(I) tricarbonyl cysteine at 5 min post injection showed high concentrated activity in the kidney. And in the 15, 30 min post injection images, most activity appeared in the bladder without a residue in other organs. The ^99m^Tc(I) tricarbonyl cysteine exhibited biological behavior comparable to ^99m^Tc‐MAG~3~ and it is expected to have diagnostic potential for imaging renal function in nuclear medicine. Copyright © 2004 John Wiley & Sons, Ltd.