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(R)- and (S)-8-acetyl-2-(dipropylamino)tetralin (LY-41): two novel 5-HT1A receptor agonists

✍ Scribed by Yu Hong; Liu Ye; Uli Hacksell; Tommy Lewander


Book ID
115888791
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
610 KB
Volume
231
Category
Article
ISSN
0014-2999

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Synthesis of R-(+)- and S-(−)-8-hydroxy-
✍ M. J. Ackland; L. G. Dring; J. R. Jones; N. Gilon 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 364 KB

## Abstract The title compounds were synthesised in 7 steps from 1,7‐dihydroxynaphthalene as follows: 1,7‐dihydroxynaphthalene was methylated and subjected to a Birch reduction to yield 8‐methoxy‐2‐tetralone. Reductive amination with sodium cyanoboro[^3^H]hydride and n‐propylamine gave 8‐methoxy‐2‐