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Derivatives of ( R )- and ( S )-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin: Synthesis and Interactions with 5-HT 1A Receptors

✍ Scribed by Backlund Höök, Berit; Cortizo, Lourdes; Johansson, Anette M.; Westlind-Danielsson, Anita; Mohell, Nina; Hacksell, Uli

Book ID
127084644
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
179 KB
Volume
39
Category
Article
ISSN
0022-2623

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Synthesis of R-(+)- and S-(−)-8-hydroxy-
Synthesis of R-(+)- and S-(−)-8-hydroxy-2-(N, N-dipropylamino)-[2-3H] tetralin. HCl (8-OH-DPAT) a 5HT1A receptor agonist
✍ M. J. Ackland; L. G. Dring; J. R. Jones; N. Gilon 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 364 KB

## Abstract The title compounds were synthesised in 7 steps from 1,7‐dihydroxynaphthalene as follows: 1,7‐dihydroxynaphthalene was methylated and subjected to a Birch reduction to yield 8‐methoxy‐2‐tetralone. Reductive amination with sodium cyanoboro[^3^H]hydride and n‐propylamine gave 8‐methoxy‐2‐