Analysis of molecular determinants of affinity and relative efficacy of a series of R- and S-2-(dipropylamino)tetralins at the 5-HT1A serotonin receptor
✍ Scribed by J Tracy Alder; Uli Hacksell; Philip G Strange
- Book ID
- 110007637
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 276 KB
- Volume
- 138
- Category
- Article
- ISSN
- 0007-1188
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📜 SIMILAR VOLUMES
## Abstract The title compounds were synthesised in 7 steps from 1,7‐dihydroxynaphthalene as follows: 1,7‐dihydroxynaphthalene was methylated and subjected to a Birch reduction to yield 8‐methoxy‐2‐tetralone. Reductive amination with sodium cyanoboro[^3^H]hydride and n‐propylamine gave 8‐methoxy‐2‐
Butyrophenone Analogues in the Carbazole Series: Synthesis and Determination of Affinities at D 2 and 5-HT 2A Receptors. -As a part of an ongoing research program on new CNS acting agents two approaches to compounds such as (VII) are presented. The most promising compound (VIIc), named QF 2004B, is