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Quantitative structure activity relationship (QSAR) of competitive N-methyl-D-aspartate (NMDA) antagonists

✍ Scribed by KORKUT, ANIL; VARNALI, TEREZA

Book ID
120574664
Publisher
Taylor and Francis Group
Year
2003
Tongue
English
Weight
578 KB
Volume
101
Category
Article
ISSN
0026-8976

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## Abstract Syntheses of a series of enantiomerically pure, substituted analogues 7b–t of SDZ EAB 515 (7a) were described (__Schemes 1__ and __2__). Affinites for the NMDA receptor were measured ([^3^H]CGP‐39653 binding assay) and competitive NMDA antagonistic potencies determined in a functional t