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Structure-activity relationships of competitive NMDA receptor antagonists

✍ Scribed by Nam S. Cheung; Daniel O'Callaghan; Mary C. Ryan; Renée Dutton; Margaret G. Wong; Philip M. Beart

Book ID
115891379
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
528 KB
Volume
313
Category
Article
ISSN
0014-2999

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The N-methyl-D-aspartate (NMDA)-subtype of glutamate receptors has been well described as a result of the early appearance of NMDA antagonists, but no potent antagonist for the "non-NMDA" glutamate receptors has been available. Quinoxaline- diones have now been found to be potent and competitive ant