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Anticonvulsant activity of competitive antagonists of NMDA receptor in genetically epilepsy-prone rats

✍ Scribed by Giovambattista De Sarro; Angela De Sarro

Book ID
115887362
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
739 KB
Volume
215
Category
Article
ISSN
0014-2999

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Acute administration (0.4-12 mumol/kg, i.p.) of the NMDA antagonist D(-)CPPene (3-(2-carboxypiperazin-4-yl)propenyl-1-phosphonic acid; molecular weight = 250.2) dose-dependently reduced the incidence of sound-induced clonic seizures in genetically epilepsy-prone (GEP) rats. The ED50 value against cl