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Further evidence of anticonvulsant role for 5-hydroxytryptamine in genetically epilepsy-prone rats

โœ Scribed by Qing-Shan Yan; Phillip C. Jobe; John W. Dailey

Book ID
117960181
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
989 KB
Volume
115
Category
Article
ISSN
0007-1188

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Acute administration (0.4-12 mumol/kg, i.p.) of the NMDA antagonist D(-)CPPene (3-(2-carboxypiperazin-4-yl)propenyl-1-phosphonic acid; molecular weight = 250.2) dose-dependently reduced the incidence of sound-induced clonic seizures in genetically epilepsy-prone (GEP) rats. The ED50 value against cl