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Anticonvulsant properties of D-20443 in genetically epilepsy-prone rats: prediction of clinical response

โœ Scribed by John W. Dailey; Jae Hoon Cheong; Kwang Ho Ko; Leah E. Adams-Curtis; Phillip C. Jobe


Book ID
116124875
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
391 KB
Volume
195
Category
Article
ISSN
0304-3940

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Acute administration (0.4-12 mumol/kg, i.p.) of the NMDA antagonist D(-)CPPene (3-(2-carboxypiperazin-4-yl)propenyl-1-phosphonic acid; molecular weight = 250.2) dose-dependently reduced the incidence of sound-induced clonic seizures in genetically epilepsy-prone (GEP) rats. The ED50 value against cl