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Comparison of competitive vs non-competitive N-methyl-D aspartate (NMDA) antagonists in the treatment of experimental brain injury in the rat

✍ Scribed by Macchi, Veronica; Porzionato, Andrea; Morra, Aldo; D’Antoni, Anthony V.; Tubbs, R. Shane; De Caro, Raffaele


Book ID
121911553
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
103 KB
Volume
16
Category
Article
ISSN
0197-0186

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Primary cultures of embryonic rat cerebral cortex were treated after 17 days in vitro for 10 min with a single dose of the non-competitive antagonists of Nmethyl-D-aspartate (NMDA) receptor MK 801, TCP, and GK 11. They were then maintained in vitro for 31, 59, or 73 days, and then processed for the