Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat
β Scribed by ZR Vlahcevic; RT Stravitz; DM Heuman; PB Hylemon; WM Pandak
- Book ID
- 118519722
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 381 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0016-5085
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π SIMILAR VOLUMES
Bile acid synthesis is believed to be regulated by bile salts returning to the liver via the portal vein and suppressing cholesterol 7a-hydroxylase, the rate-limiting enzyme in the bile acid biosynthesis pathway. In order to characterize the relative effectiveness of bile salts in regulating bile ac
During biosynthesis of bile acid, carbons 25-26-27 are removed from the cholesterol side chain. Side-chain oxidation begins either with hydroxylation at the 26-position, in which case the three-carbon fragment is released as propionic acid, or with hydroxylation at the 25-position, in which case the