𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Quantification of the effect of water exchange in dynamic contrast MRI perfusion measurements in the brain and heart

✍ Scribed by Henrik B.W. Larsson; Sverre Rosenbaum; Thomas Fritz-Hansen

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
279 KB
Volume
46
Category
Article
ISSN
0740-3194

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Measurement of myocardial and brain perfusion when using exogenous contrast agents (CAs) such as gadolinium‐DTPA (Gd‐DTPA) and MRI is affected by the diffusion of water between compartments. This water exchange may have an impact on signal enhancement, or, equivalently, on the longitudinal relaxation rate, and could therefore cause a systematic error in the calculation of perfusion (F) or the perfusion‐related parameter, the unidirectional influx constant over the capillary membranes (K~i~). The aim of this study was to quantify the effect of water exchange on estimated perfusion (F or K~i~) by using a realistic simulation. These results were verified by in vivo studies of the heart and brain in humans. The conclusion is that water exchange between the vascular and extravascular extracellular space has no effect on K~i~ estimation in the myocardium when a normal dose of Gd‐DTPA is used. Water exchange can have a significant effect on perfusion estimation (F) in the brain when using Gd‐DTPA, where it acts as an intravascular contrast agent. Magn Reson Med 46:272–281, 2001. © 2001 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

On the theoretical basis of perfusion me
On the theoretical basis of perfusion measurements by dynamic susceptibility contrast MRI
✍ V.G. Kiselev 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 226 KB

## Abstract A quantitative analysis was undertaken to calibrate the perfusion quantification technique based on tracking the first pass of a bolus of a blood pool contrast agent. A complete simulation of the bolus passage, of the associated changes in the __T__~2~ and __T__ signals, and of the data

Determining and optimizing the precision
Determining and optimizing the precision of quantitative measurements of perfusion from dynamic contrast enhanced MRI
✍ Brian M. Dale; John A. Jesberger; Jonathan S. Lewin; Claudia M. Hillenbrand; Jef 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 328 KB

## Abstract ## Purpose To examine the sensitivity of quantitative dynamic contrast enhanced MRI (DCE‐MRI) perfusion maps to errors in the various source images and to determine optimal imaging parameters for reducing this sensitivity. ## Materials and Methods A detailed analysis of the precision

Precision in measurements of perfusion a
Precision in measurements of perfusion and microvascular permeability with T1-weighted dynamic contrast-enhanced MRI
✍ Lucy E. Kershaw; David L. Buckley 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 286 KB

## Abstract Dynamic contrast‐enhanced MRI is used to estimate microvascular parameters by tracer kinetics analysis. The time for the contrast agent to travel from the artery to the tissue of interest (bolus arrival time (BAT)) is an important parameter that must be measured in such studies because

Cellular-interstitial water exchange and
Cellular-interstitial water exchange and its effect on the determination of contrast agent concentration in vivo: Dynamic contrast-enhanced MRI of human internal obturator muscle
✍ David L. Buckley; Lucy E. Kershaw; Greg J. Stanisz 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 404 KB

## Abstract The purpose of this study was to assess the effects of cellular‐interstitial water exchange on estimates of tracer kinetics parameters obtained using rapid dynamic contrast‐enhanced (DCE) MRI. Data from the internal obturator muscle of six patients were examined using three models of wa

Perfusion MRI of the human brain with dy
Perfusion MRI of the human brain with dynamic susceptibility contrast: Gradient-echo versus spin-echo techniques
✍ Oliver Speck; Linda Chang; N. Menaka DeSilva; Thomas Ernst 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 435 KB 👁 2 views

In this study, spin-echo and gradient-echo-based perfusion magnetic resonance imaging (MRI) techniques are systematically compared with respect to their application in the human brain. Six healthy subjects were evaluated with both techniques consecutively and injected twice with a gadolinium-based c