## Abstract Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system, which is thought to be a result of the reactivation of JC virus (JCV), a human polyomavirus. The disease occurs in individuals with immunosuppression and in recent years there has
✦ LIBER ✦
Quantification of human polyomavirus JC in brain tissue and cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy by competitive PCR
✍ Scribed by Klaus Drews; Tarig Bashir; Kristina Dörries
- Book ID
- 114140855
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 292 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0166-0934
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Progressive multifocal leukoencephalopathy (PML) is a lytic infection of oligodendrocytes by the human papovavirus JC. Patients with defects in cell-mediated immunity are at risk for active disease: a usually lethal demyelination of the brain. PML develops in at least 4% of patients with the acquire