Progressive multifocal leukoencephalopathy (PML), a viral-induced demyelinating disease, is becoming relatively common, while many diagnostic and pathogenetic aspects remain to be clarified. A study was therefore undertaken in 64 AIDS patients suffering from various neurological disorders, including
Detection of JC virus DNA in the cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy
β Scribed by Patricia E. Gibson; Wendy A. Knowles; Julian F. Hand; David W. G. Brown
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 445 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0146-6615
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A case of acute progressive multifocal leukoencephalopathy (PML) with hyper IgM syndrome 1 is reported. Viral DNA and VP1 protein of JC virus (JCV) and BK virus (BKV) were detected by immunohistochemistry, in situ hybridization, seminested polymerase chain (PCR) and PCR-restriction enzyme analysis.
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