Detection of JC virus by polymerase chain reaction in cerebrospinal fluid from two patients with progressive multifocal leukoencephalopathy
β Scribed by A. Telenti; W. F. Marshall; A. J. Aksamit; J. D. Smilack; T. F. Smith
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 318 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0934-9723
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Progressive multifocal leukoencephalopathy (PML) is a lytic infection of oligodendrocytes by the human papovavirus JC. Patients with defects in cell-mediated immunity are at risk for active disease: a usually lethal demyelination of the brain. PML develops in at least 4% of patients with the acquire
## Abstract Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system, which is thought to be a result of the reactivation of JC virus (JCV), a human polyomavirus. The disease occurs in individuals with immunosuppression and in recent years there has
## Abstract __JC virus__ (JCV) causes progressive multifocal leukoencephalopathy under conditions of immunosuppression, especially associated with HIV. Despite the high prevalence of HIVβ1 infection, few cases of progressive multifocal leukoencephalopathy have been reported and only a small number