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Putting the Parkin into Parkinson's

✍ Scribed by Nussbaum, Robert L.


Book ID
109753729
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
285 KB
Volume
392
Category
Article
ISSN
0028-0836

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## Abstract Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic