Parkin and Parkinson's: More than homonymy?
β Scribed by Olga Corti; Alexis Brice
- Book ID
- 101462423
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 106 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0364-5134
- DOI
- 10.1002/ana.1143
No coin nor oath required. For personal study only.
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## Abstract Parkin, an E2βdependent ubiquitin protein ligase, carries pathogenic mutations in patients with autosomal recessive juvenile parkinsonism, but its role in the lateβonset form of Parkinson's disease (PD) is not firmly established. Previously, we detected linkage of idiopathic PD to the r
## Abstract We report on an evaluation of coding variants within the parkin gene to assess their frequency in a North American clinical series of 313 Parkinson's disease (PD) cases and 192 unrelated controls. We hypothesized that the carrier frequency of parkin coding mutations, exon deletions, or
## Abstract Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic