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Purification and stability of specifically tritium labelled lysine vasopressin (Tyrosine2-3-T-lysine8-vasopressin)

✍ Scribed by L. Carlsson; V. Pliska; N. A. Thorn


Book ID
112646960
Publisher
Springer
Year
1969
Tongue
English
Weight
115 KB
Volume
25
Category
Article
ISSN
1420-682X

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Synthesis of specifically tritium-labell
✍ Ingvar SjΓΆholm; Lars Carlsson πŸ“‚ Article πŸ“… 1967 πŸ› John Wiley and Sons 🌐 French βš– 663 KB

Highly tritium-iabelled oxy tocin and lysine-vasopressin have been synthesized. L-tyrosine-3-3H was prepared from L-3-iodotyrosine and tritium gas in methanolic potassium hydroxide with palladium on active carbon as a catalyst. The tritiated oxytocin and lysinevasopressin were obtained from the trit

Synthesis and specific tritium labelling
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The specific labelling of the octapeptide1des-9-gl cinamide--8-lysine-vasopressin in the tyrosine and phenylalanine 3 residues with tritium is described. The 3.5-dibromotyrosine and 4-chloro--phenylalanine containing precursor peptides for labelling were synthesized by solid phase peptide synthesis.