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PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia

✍ Scribed by Kleppe, M.; Soulier, J.; Asnafi, V.; Mentens, N.; Hornakova, T.; Knoops, L.; Constantinescu, S.; Sigaux, F.; Meijerink, J. P.; Vandenberghe, P.

Book ID
111647618
Publisher
American Society of Hematology
Year
2011
Tongue
English
Weight
505 KB
Volume
117
Category
Article
ISSN
0006-4971

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## Abstract T‐cell acute lymphoblastic leukemia (T‐ALL) is the result of multiple oncogenic insults of thymocytes. Recently, new __ABL1__ fusion genes have been identified that provide proliferation and survival advantage to lymphoblasts. These are the __NUP214‐ABL1__ fusion gene, on amplified epis