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Prototype for a new family of De Novo proteins

โœ Scribed by Bruce C. Gibb; Adam R. Mezo; John C. Sherman


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
250 KB
Volume
36
Category
Article
ISSN
0040-4039

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We describe a new method for de novo design of molecules that bind to protein active sites. The method, CONCEPTS (Creation of Novel Compounds by Evaluation of Particles at Target Sites), places a group of atom-like particles in the site. The particles are free to move within the site to improve bind