Carbohydrates as templates for control of distance-geometry in de novo-designed proteins
β Scribed by K.J. Jensen; J. Brask
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 194 KB
- Volume
- 59
- Category
- Article
- ISSN
- 1420-682X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Stereochemistry could be a powerful variable for conformational tune up of polypeptides for de novo design. It may be also useful probe of possible role of interamide energetics in selection and stabilization of conformation. The homopolypeptides AcβXxx~30~βNHMe, with Xxx = Ala, Val, an
The solution to the protein folding problem lies in defining the relative energetic contributions of short-range and long-range interactions. In other words, the tendency of a stretch of amino acids to adopt a final secondary structural fold is context dependent. Our approach to this problem is to a