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Proteomic analysis of dopamine and α-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis

✍ Scribed by Tiziana Alberio; Alessandra Maria Bossi; Alberto Milli; Elisa Parma; Marzia Bruna Gariboldi; Giovanna Tosi; Leonardo Lopiano; Mauro Fasano

Book ID
111313709
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
501 KB
Volume
277
Category
Article
ISSN
1432-1327

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## Abstract Parkinson's disease (PD) is characterized by loss of nigral dopaminergic (DAergic) neurons and presence of Lewy bodies, whose major component is α‐synuclein. We had previously generated transgenic mice termed __Syn130m__ that express truncated human α‐synuclein (amino acid residues 1–13