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Interaction of α-synuclein and tau genotypes in Parkinson's disease

✍ Scribed by Catherine E. Mamah; Timothy G. Lesnick; Sarah J. Lincoln; Kari J. Strain; Mariza de Andrade; James H. Bower; J. Eric Ahlskog; Walter A. Rocca; Matthew J. Farrer; Demetrius M. Maraganore

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 87 KB
Volume: 57
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.20387

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## Abstract Dementia is a common complication of Parkinson's disease (PD). It correlates significantly with the presence of cortical, limbic or nigral Lewy bodies, mainly constituted of alpha‐synuclein. Mutations of the alpha‐synuclein gene (SNCA) have been linked to rare familial forms of PD, whil