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Tau and α-synuclein in susceptibility to, and dementia in, Parkinson's disease

✍ Scribed by An Goris; Caroline H. Williams-Gray; Graeme R. Clark; Thomas Foltynie; Simon J. G. Lewis; Joanne Brown; Maria Ban; Maria G. Spillantini; Alastair Compston; David J. Burn; Patrick F. Chinnery; Roger A. Barker; Stephen J. Sawcer

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
209 KB
Volume
62
Category
Article
ISSN
0364-5134

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## Abstract Dementia is a common complication of Parkinson's disease (PD). It correlates significantly with the presence of cortical, limbic or nigral Lewy bodies, mainly constituted of alpha‐synuclein. Mutations of the alpha‐synuclein gene (SNCA) have been linked to rare familial forms of PD, whil