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α-Synuclein promoter confers susceptibility to Parkinson's disease

✍ Scribed by Philippe Pals; Sarah Lincoln; Jonathan Manning; Michael Heckman; Lisa Skipper; Mary Hulihan; Marleen Van den Broeck; Tim De Pooter; Patrick Cras; Julia Crook; Christine Van Broeckhoven; Matt J. Farrer


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
164 KB
Volume
56
Category
Article
ISSN
0364-5134

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## Abstract Dementia is a common complication of Parkinson's disease (PD). It correlates significantly with the presence of cortical, limbic or nigral Lewy bodies, mainly constituted of alpha‐synuclein. Mutations of the alpha‐synuclein gene (SNCA) have been linked to rare familial forms of PD, whil