Pathogenesis of parkinson's disease: dopamine, vesicles and α-synuclein
✍ Scribed by Lotharius, Julie; Brundin, Patrik
- Book ID
- 109964411
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 988 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1471-0048
- DOI
- 10.1038/nrn983
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Genetic studies of Parkinson's disease over the last decade or more have revolutionized our understanding of this condition. α‐Synuclein was the first gene to be linked to Parkinson's disease, and is arguably the most important: the protein is the principal constituent of Lewy bodies, a
The aggregation of normally soluble a-synuclein in the dopaminergic neurons of the substantia nigra is a crucial step in the pathogenesis of Parkinson's disease. Oxidative stress is believed to be a contributing factor in this disorder. Because it lacks Trp and Cys residues, mild oxidation of a-synu
The letter by Papapetropoulos and colleagues presents an additional study correlating ␣-synuclein expression levels and sporadic PD. Previously we and others published studies of mRNA levels of SNCA in PD brains that have been performed using different methods. Some are in agreement with our results