Gene dosage analysis of α-synuclein (SNCA) in patients with Parkinson's disease
✍ Scribed by Hao Deng; Wenjie Xie; Yi Guo; Weidong Le; Joseph Jankovic
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 50 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0885-3185
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📜 SIMILAR VOLUMES
## Abstract Missense mutations of the α‐synuclein gene have been reported to explain a few kindreds with autosomal dominant Parkinson's disease (PD). In order to identify mutations in our PD patients, we have screened the coding region and 5′flanking region of the gene. DNA samples from 50 patients
The letter by Papapetropoulos and colleagues presents an additional study correlating ␣-synuclein expression levels and sporadic PD. Previously we and others published studies of mRNA levels of SNCA in PD brains that have been performed using different methods. Some are in agreement with our results