The letter by Papapetropoulos and colleagues presents an additional study correlating ␣-synuclein expression levels and sporadic PD. Previously we and others published studies of mRNA levels of SNCA in PD brains that have been performed using different methods. Some are in agreement with our results
Reply: Expression of α-Synuclein mRNA in Parkinson's disease
✍ Scribed by Ornit Chiba-Falek; Grisel J. Lopez; Robert L. Nussbaum
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 37 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0885-3185
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The presynaptic protein alpha-synuclein is considered to play an important role in the pathophysiology of Parkinson's disease (PD). Point mutations in the alpha-synuclein gene have been demonstrated in familial PD and alpha-synuclein is a major component of Lewy bodies, the pathological hallmark of
## Abstract The expression of α‐synuclein gene can be influenced by the genomic load and/or epigenetic factors. By using quantitative real‐time polymerase chain reaction techniques, we demonstrated that the α‐synuclein gene mRNA expression in sporadic PD did not differ from healthy controls (median
## Abstract Genetic studies of Parkinson's disease over the last decade or more have revolutionized our understanding of this condition. α‐Synuclein was the first gene to be linked to Parkinson's disease, and is arguably the most important: the protein is the principal constituent of Lewy bodies, a
## Abstract Lewy bodies, the pathological hallmark of Parkinson's disease (PD), consist largely of α‐synuclein, a 14.5‐kDa presynaptic neuronal protein implicated in familial PD. An increased copy number and elevated expression of wild‐type α‐synuclein (__SNCA__) has been shown to cause early‐onset