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Alpha-synuclein mRNA expression in sporadic Parkinson's disease

✍ Scribed by Eng-King Tan; Van R. Chandran; Stephanie Fook-Chong; Hui Shen; Kenneth Yew; Mei-Lin Teoh; Yih Yuen; Yi Zhao

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
79 KB
Volume
20
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

The expression of α‐synuclein gene can be influenced by the genomic load and/or epigenetic factors. By using quantitative real‐time polymerase chain reaction techniques, we demonstrated that the α‐synuclein gene mRNA expression in sporadic PD did not differ from healthy controls (median [range] 0.110 ]0.012–0.628] vs. 0.120 [0.028–0.447]; P = 0.15). There was no difference in the α‐synuclein gene dosage between PD patients with high and low mRNA expression. Multivariate analysis did not reveal age, gender, or cigarette smoking as confounding variables. Our study suggests that there was no significant alteration of α‐synuclein mRNA expression in our sporadic PD patients compared to controls. However, the role of α‐synuclein mRNA expression in select groups of sporadic PD patients and its interaction with environmental agents need to be further determined. © 2005 Movement Disorder Society

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