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Protein Structural Change upon Ligand Binding Correlates with Enzymatic Reaction Mechanism

✍ Scribed by Ryotaro Koike; Takayuki Amemiya; Motonori Ota; Akinori Kidera


Book ID
116663784
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
430 KB
Volume
379
Category
Article
ISSN
0022-2836

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## Abstract Coupling between proteins motion and ligand binding can be well explained by the linear response theory (Ikeguchi, M.; Ueno, J.; Sato, M.; Kidera, A. Phys Rev Lett 2005, 94, 078102.), in which the structural change is treated as a response to ligand binding. The prediction accuracy of s

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Growth factor receptor-bound protein 2 (Grb2) is an extensively studied adaptor protein involved in cell signaling. Grb2 is a highly flexible protein composed of a single SH2 domain flanked by two SH3 domains. Here we report on the structural dynamic effects upon interaction of a phosphopeptide liga