Protein Structural Change upon Ligand Binding Correlates with Enzymatic Reaction Mechanism
β Scribed by Ryotaro Koike; Takayuki Amemiya; Motonori Ota; Akinori Kidera
- Book ID
- 116663784
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 430 KB
- Volume
- 379
- Category
- Article
- ISSN
- 0022-2836
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## Abstract Coupling between proteins motion and ligand binding can be well explained by the linear response theory (Ikeguchi, M.; Ueno, J.; Sato, M.; Kidera, A. Phys Rev Lett 2005, 94, 078102.), in which the structural change is treated as a response to ligand binding. The prediction accuracy of s
Growth factor receptor-bound protein 2 (Grb2) is an extensively studied adaptor protein involved in cell signaling. Grb2 is a highly flexible protein composed of a single SH2 domain flanked by two SH3 domains. Here we report on the structural dynamic effects upon interaction of a phosphopeptide liga