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Long-Range Correlated Motion Changes with Protein-Ligand Binding

✍ Scribed by Niessen, Katherine A.; Xu, Mengyang; Snell, Edward; Markelz, Andrea

Book ID
123186907
Publisher
Biophysical Society
Year
2014
Tongue
English
Weight
148 KB
Volume
106
Category
Article
ISSN
0006-3495

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## Abstract The binding of 2‐amino‐5‐methylthiazole to the W191G cavity mutant of cytochrome c peroxidase is an ideal test case to investigate the entropic contribution to the binding free energy due to changes in receptor flexibility. The dynamic and thermodynamic role of receptor flexibility are