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Protein stability induced by ligand binding correlates with changes in protein flexibility

✍ Scribed by Celej, María Soledad (author);Montich, Guillermo G. (author);Fidelio, Gerardo D. (author)

Book ID
119824151
Publisher
Wiley
Year
2003
Tongue
English
Weight
159 KB
Volume
12
Category
Article
ISSN
0961-8368

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## Abstract The binding of 2‐amino‐5‐methylthiazole to the W191G cavity mutant of cytochrome c peroxidase is an ideal test case to investigate the entropic contribution to the binding free energy due to changes in receptor flexibility. The dynamic and thermodynamic role of receptor flexibility are