✦ LIBER ✦

Protein kinases: A diverse family of related proteins

✍ Scribed by Susan S. Taylor

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 729 KB
Volume: 7
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950070106

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✦ Synopsis

Homologies in amino-acid sequence indicate that all known protein kinases share a conserved catalytic core, and, thus, belong to a relatedfamily ofproteins that have evolved in part from a common ancestoral origin. This family includes cellular kinases, oncogenic viral kinases and their protooncogene counterparts, and growth factor receptors. One of the simplest and certainly the best characterized of the protein kinases at the biochemical level is the kinase that is activated in response to CAMP. The properties of this CAMP-dependent protein kinase are reviewed with particular emphasis on the features of nucleotide binding and catalytic mechanism that are likely to be shared by all protein kinases.

In spite of this conserved catalytic core, these kinases vary widely in overall structure and in the mechanisms by which each is regulated, and these diferences also are compared.

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