✦ LIBER ✦

Growth-related protein kinases

✍ Scribed by Ray K. Ralph; Sandra Darkin-Rattray; Phillip Schofield

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 465 KB
Volume: 12
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950120305

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A protein kinase cascade is involved in the action of some mitogens. The cascade begins with receptor tyrosine kinase activation by growth factors. The resulting signal is transmitted into cells via phospholipid metabolism which produces a variety of second messengers and by intracellular protein kinase activation. The signal is then propagated and disseminated via a network of other proteln kinases and protein phosphatases. Recent research suggests that ribosomal protein S6 kinase and casein kinase II are two important elements in the kinase cascade that leads to the initiation of growth. The nature and some properties of these hitherto lesser known enzymes is considered.

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