Protein Engineering: Modified Hemoglobin as a Blood Substitute
β Scribed by Dr. Timm-H. Jessen; Dr. Rolf Hilgenfeld
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 265 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0044-8249
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Long-term preservation of hemoglobin (Hb) vesicles, the so-called artificial red cell (ARC), in dry powder was studied. Carbonylhemoglobin (COHb) was encapsulated in the vesicle of 1,2-bis(2,4-octadecadienoyl)-sn-glycero-3-phosphocholine (DODPC) and the polymerizable membrane components were polymer
Hemoglobin (Hb) i n solution is capable of transporting oxygen and could thus be considered as an ideal red cell substitute. However, i t presents two important drawbacks : a short vascular retention time and a high oxygen affinity. Chemical modifications