Polymer-linked hemoglobin as a potential blood substitute
β Scribed by Edith Dellacherie
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 681 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0267-6605
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π SIMILAR VOLUMES
Hemoglobin (Hb) i n solution is capable of transporting oxygen and could thus be considered as an ideal red cell substitute. However, i t presents two important drawbacks : a short vascular retention time and a high oxygen affinity. Chemical modifications
Long-term preservation of hemoglobin (Hb) vesicles, the so-called artificial red cell (ARC), in dry powder was studied. Carbonylhemoglobin (COHb) was encapsulated in the vesicle of 1,2-bis(2,4-octadecadienoyl)-sn-glycero-3-phosphocholine (DODPC) and the polymerizable membrane components were polymer
## Abstract Porosity and semipermeability, allowing lifeβsustaining small molecules to penetrate, but hemoglobin (Hb) and other enzymes to cut off, predominantly affect the functionalities of the Hbβloaded polymeric nanoparticles (HbPNPs) as blood substitutes. In this article, HbPNPs formulated in