Soluble polymers as hemoglobin carriers in blood substitutes
✍ Scribed by Dellacherie, E. ;Léonard, M.
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1985
- Weight
- 140 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0025-116X
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✦ Synopsis
Hemoglobin (Hb)
i n solution is capable of transporting oxygen and could thus be considered as an ideal red cell substitute. However, i t presents two important drawbacks : a short vascular retention time and a high oxygen affinity. Chemical modifications
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## Abstract Porosity and semipermeability, allowing life‐sustaining small molecules to penetrate, but hemoglobin (Hb) and other enzymes to cut off, predominantly affect the functionalities of the Hb‐loaded polymeric nanoparticles (HbPNPs) as blood substitutes. In this article, HbPNPs formulated in
New bioerodible materials, which are noncrosslinked and water-soluble copolymers of quaternary amines, and alkyl (meth)acrylate were synthesized and then bound with anionic drugs (sodium sulfathiazole and diclofenac sodium) to form waterinsoluble complexes. Sodium sulfathiazole was bound to the copo