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Protection against cisplatin-induced nephrotoxicity in mice byCurcuma comosaRoxb. ethanol extract

✍ Scribed by Surawat Jariyawat; Pranida Kigpituck; Kanoknetr Suksen; Aporn Chuncharunee; Arusa Chaovanalikit; Pawinee Piyachaturawat

Book ID
107343739
Publisher
Springer Japan
Year
2009
Tongue
Japanese
Weight
462 KB
Volume
63
Category
Article
ISSN
1340-3443

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Key words: nephrotoxicity; cisplatin; radical scavengers; methimazole; rat In adult rats 6 mg kg -1 body wt. cisplatin given i.p. was nephrotoxic. Four days of i.p. treatment with 40 mg kg -1 body wt. methimazole, which started 1 day before CP, prevented increases in blood urea nitrogen and in the r