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Promotion by dichloroacetic acid and trichloroacetic acid of N-methyl-N-nitrosourea-initiated cancer in the liver of female B6C3F1 mice

✍ Scribed by Michael A Pereira; J.Barry Phelps

Book ID
116123462
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
782 KB
Volume
102
Category
Article
ISSN
0304-3835

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The effect of dichloroacetic acid and tr
The effect of dichloroacetic acid and trichloroacetic acid on DNA methylation and cell proliferation in B6C3F1 mice
✍ Rongrong Ge; Siming Yang; Paula M. Kramer; Lianhui Tao; Michael A. Pereira πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 181 KB

## Abstract The chlorine disinfection by‐products, dichloroacetic acid (DCA) and trichloroacetic acid (TCA), are carcinogenic in mouse liver. We have previously reported that DCA and TCA induced DNA hypomethylation in mouse liver. In the present study, we determined the temporal association for DNA