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Progress in medicinal chemistry, vol. 26: edited by G.P. Ellis and G.B. West. Elsevier Science Publishers, 1989. VIII + pp. 586, US$ 197.25; Dfl. 375.00

Book ID: 103629267
Publisher: Elsevier Science
Year: 1989
Tongue: French
Weight: 164 KB
Volume: 24
Category: Article
ISSN: 0223-5234
DOI: 10.1016/0223-5234(89)90065-2

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The integral in Eq. 15 was evaluated numerically by a commonly used integration algorithm (4). Special caution must be taken in applying a loading dose of a nonlinear drug. It may not be desirable to use a loading dose for a drug showing a narrow therapeutic index. However, in certain clinical situ