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Progress in medicinal chemistry 24: edited by G. P. Ellis and G. B. West. Elsevier, Amsterdam, 1987, pp. 360, Dfl 275.00

Book ID: 103629075
Publisher: Elsevier Science
Year: 1987
Tongue: French
Weight: 157 KB
Volume: 22
Category: Article
ISSN: 0223-5234
DOI: 10.1016/0223-5234(87)90307-2

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The integral in Eq. 15 was evaluated numerically by a commonly used integration algorithm (4). Special caution must be taken in applying a loading dose of a nonlinear drug. It may not be desirable to use a loading dose for a drug showing a narrow therapeutic index. However, in certain clinical situ