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Progress in medicinal chemistry: Ellis, G.P. and West, G.B. (Eds.), Vol. 25, 352 pp. Elsevier, Amsterdam, 1988. Price dfl. 270.00 ISBN 0444-80965-1

✍ Scribed by F. Borek

Book ID: 103571329
Publisher: Elsevier Science
Year: 1990
Tongue: English
Weight: 73 KB
Volume: 19
Category: Article
ISSN: 0162-3109
DOI: 10.1016/0162-3109(90)90050-o

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The integral in Eq. 15 was evaluated numerically by a commonly used integration algorithm (4). Special caution must be taken in applying a loading dose of a nonlinear drug. It may not be desirable to use a loading dose for a drug showing a narrow therapeutic index. However, in certain clinical situ