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Programmable Oligomers for Minor Groove DNA Recognition

✍ Scribed by Doss, Raymond M.; Marques, Michael A.; Foister, Shane; Chenoweth, David M.; Dervan, Peter B.


Book ID
118192867
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
853 KB
Volume
128
Category
Article
ISSN
0002-7863

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This review surveys the crystal structures between minor groove drugs and oligonucleotides, of which over thirty have now been determined. The various factors that are involved in the observed A/T sequence selectivity of these drugs are examined in structural terms. The roles of, in particular, hydr