𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Crystallographic insights into DNA minor groove recognition by drugs

✍ Scribed by Stephen Neidle

Publisher
Wiley (John Wiley & Sons)
Year
1997
Tongue
English
Weight
385 KB
Volume
44
Category
Article
ISSN
0006-3525

No coin nor oath required. For personal study only.

✦ Synopsis

This review surveys the crystal structures between minor groove drugs and oligonucleotides, of which over thirty have now been determined. The various factors that are involved in the observed A/T sequence selectivity of these drugs are examined in structural terms. The roles of, in particular, hydrogen-bond recognition and sequence-dependent groove width, are assessed, and as a consequence the minor groove drugs have been classified into two categories, dependent on the relative roles played by these two factors in sequence recognition. Implications for the recognition of non-A/T sequences are discussed.

📜 SIMILAR VOLUMES

ChemInform Abstract: Recognition in the
ChemInform Abstract: Recognition in the Minor Groove of Double-Stranded DNA by Microgonotropens
✍ Alexander L. Satz; Thomas C. Bruice 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 24 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v